发明名称 |
PROCEDE DE PREPARATION PAR FILTRATION D'UNE SOLUTION DE FACTEUR VIII SECURISEE VIRALEMENT |
摘要 |
The invention concerns a method for preparing by filtration a virally secure factor VIII solution and essentially free of high molecular weight vWF which consists in: preparing a solution containing high or very high purity factor VIII or essentially free of complexes with VIII-vWf factor high molecular weight; optionally carrying out a step (a) if required, of chemical breakdown of the complexes with VIII-vWF factor high molecular weight and obtaining a solution essentially free of factor VIII associated with high molecular weight vWF; carrying out a step (b) filtering said solution essentially free of factor VIII associated with high molecular weight vWF on a hydrophilic filter with porosity as low as 15 nm.
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申请公布号 |
FR2772381(A1) |
申请公布日期 |
1999.06.18 |
申请号 |
FR19970015888 |
申请日期 |
1997.12.15 |
申请人 |
LABORATOIRE FRANCAIS DU FRACTIONNEMENT ET DES BIOTECHNOLOGIES |
发明人 |
CHTOUROU ABDESSATAR SAMI;NOGRE MICHEL;PORTE PIERRE |
分类号 |
A61K38/22;A61K35/16;A61K38/00;A61K38/43;A61P7/04;C07K1/34;C07K14/755;(IPC1-7):C07K1/34;A61K38/37 |
主分类号 |
A61K38/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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