发明名称 |
BICYCLENE SUBSTITUTED BY AN AMINOCARBONYL RADICAL, THE PRODUCTION AND USE THEREOF AS A MEDICAMENT |
摘要 |
The present invention relates to bicyclene of general formula (I) substituted by an aminocarbonyl radical, wherein R1-R6, X1-X3, Y1-Y2 are defined as in claim 1 and the tautomers, stereoisomers, mixtures and salts thereof have valuable properties. The compounds of general formula (I), wherein X3 is a cyano group, represent valuable intermediate products in the production of the other compounds in general formula (I). The compounds of general formula (I), wherein X3 is an amino, 2-amino-1H-imidazolyl or RaNH-C(C=NH) group, and the tautomers and stereoisomers thereof have valuable pharmacological properties, especially an antithrombotic effect which is based on a thrombin inhibiting effect. |
申请公布号 |
WO9929670(A2) |
申请公布日期 |
1999.06.17 |
申请号 |
WO1998EP07958 |
申请日期 |
1998.12.08 |
申请人 |
BOEHRINGER INGELHEIM PHARMA KG;SOYKA, RAINER;HECKEL, ARMIN;LEHMANN-LINTZ, THORSTEN;WALTER, RAINER;WIENEN, WOLFGANG;STASSEN, JEAN-MARIE |
发明人 |
SOYKA, RAINER;HECKEL, ARMIN;LEHMANN-LINTZ, THORSTEN;WALTER, RAINER;WIENEN, WOLFGANG;STASSEN, JEAN-MARIE |
分类号 |
C07C257/18;C07C311/21;C07D213/70;C07D213/74;C07D215/36;C07D215/40;C07D233/88;C07D239/42;C07D277/62;C07D285/14;C07D333/34;C07D333/38;C07D401/12;C07D409/12 |
主分类号 |
C07C257/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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