| 发明名称 |
METHODS OF PRODUCING ANTI-ANGIOGENIC PROTEINS: ENDOSTATIN, ANGIOSTATIN OR RESTIN, USING A PICHIA YEAST EXPRESSION SYSTEM |
| 摘要 |
Methods for making proteins with anti-angiogenic properties are disclosed, including angiostatin, endostatin and restin. The system used is a yeast expression system which produces biologically active proteins at high titer, specifically the Pichia pastores yeast expression system.
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| 申请公布号 |
CA2312287(A1) |
申请公布日期 |
1999.06.17 |
| 申请号 |
CA19982312287 |
申请日期 |
1998.12.08 |
| 申请人 |
BETH ISRAEL DEACONESS MEDICAL CENTER |
发明人 |
SUKHATME, VIKAS P. |
| 分类号 |
C12N15/09;A61K31/711;A61K35/12;A61K35/26;A61K35/28;A61K35/34;A61K35/407;A61K38/00;A61K38/48;A61K48/00;A61P1/04;A61P3/04;A61P9/00;A61P9/10;A61P15/18;A61P17/02;A61P17/06;A61P19/02;A61P27/02;A61P29/00;A61P35/00;A61P43/00;C07K14/78;C07K16/18;C07K16/40;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N9/68;C12N15/12;C12P21/02;C12P21/08;C12Q1/68;C12R1/645;(IPC1-7):C12N15/81;A61K38/39;C12N15/52;C12N15/62 |
主分类号 |
C12N15/09 |
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