| 摘要 |
<p>Recombinant poxvirus, specifically an avipox virus, preferably a canarypox virus, having therein a nucleic acid molecule encoding a biological response modifier, specifically a feline cytokine, or immunomodulating fragment thereof, in a non-essential region of the recombinant virus genome infect cells to express the biological immune response modifier. The recombinant poxvirus encoding a feline cytokine can be used to enhance or augment the immune response of said feline to antigenic components of infectious agents or tumors. The infected cells can be used to treat cancer in animals by intratumor administration or by in vivo treatment of tumor cells and reintroduction of the treated tumor cells. The cells also are used, in a non-replicating form, to protect felines against tumor formation.</p> |
