发明名称 |
Inhibitors of farnesyl-protein transferase |
摘要 |
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemoterapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras. |
申请公布号 |
AU1612099(A) |
申请公布日期 |
1999.06.16 |
申请号 |
AU19990016120 |
申请日期 |
1998.11.30 |
申请人 |
MERCK & CO., INC. |
发明人 |
TERRENCE M. CICCARONE;WASYL HALCZENKO;JOHN H. HUTCHINSON;WILLIAM C. LUMMA;GERALD E. STOKKER;CRAIG A. STUMP;THERESA M. WILLIAMS |
分类号 |
A61K31/415;A61K31/47;C07D235/30;C07D401/02;C07D401/06;C07D403/06;C07D471/04 |
主分类号 |
A61K31/415 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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