| 摘要 |
S- and R-isomers of 2-mercaptomethyl-3-aryl propanoic acid (IIIa-S) and (IIIa-R) are prepared by asymmetric reduction of an aryl propenoic acid (XII) in the presence of a chiral ruthenium catalyst. S- and R-isomers of 2-mercaptomethyl-3-aryl propanoic acid (IIIa-S) and (IIIa-R) are prepared by asymmetric reduction of an aryl propenoic acid (XII) in the presence of a chiral ruthenium catalyst: Ar = aryl, especially phenyl or naphthyl optionally substituted by one or more 1-4C alkyl, OH, halo, CF3, 1-4C alkoxy or alkylthio, or 3,4-methylenedioxy; R2 = -S-CO-CH3, -O-CO-CH3, or OH. |
