2-SUBSTITUTED QUINOLINES FOR TREATING LEISHMANIOSES.

摘要

PCT No. PCT/FR92/00903 Sec. 371 Date Jun. 9, 1994 Sec. 102(e) Date Jun. 9, 1994 PCT Filed Sep. 29, 1992 PCT Pub. No. WO93/07125 PCT Pub. Date Apr. 15, 1993Substituted quinolines having formula (1), wherein R1, R3, R4, R5, R6, and R7 each independently represent a hydrogen atom, a linear or branched C1-7 alkyl, alkenyl, epoxy-alkyl or mono/polyalcohol group; an amine group or an amide group, an OR group in which R is hydrogen or a C1-7 alkyl or alkenyl group or a phenyl group; and R2 is an OR group in which R is as defined above, or a C1-7 alkyl alkenyl or epoxyalkyl group, a phenyl, phenol, methylenedioxyphenyl, or dimethoxyphenyl group, or a C1-7 alkyl, alkenyl or epoxyalkyl group, a phenyl, phenol, methylenedioxyphenyl, or dimethoxphenyl group or a C1-7 alkyl, alkenyl or epoxy-alklyl group comprising at least one of the following substituents: a C1-4 alkyl or alkenyl group; a phenyl, phenol, dimethylphenyl, dimethoxyphenyl or methylenedioxphenyl group; or an OR group in which R is hydrogen or a C1-4 alkyl or alkenyl group; or an NHR group in which R is hydrogen or a C1-4 alkyl or alkenyl group; or an amide group; or else R2 and R3 together form a furan ring; and salts and derivatives thereof; are used as drugs, particularly anti-lieshmanials.