PROCESS FOR THE SYNTHESIS OF SEMI-SYNTHETIC GLYCOSAMINOGLYCANS WITH HEPARIN OR HEPARAN STRUCTURE MODIFIED IN POSITION 2 OF THE .ALPHA.-L-IDURONIC-2-0-SULFATE ACID

摘要

A process for the synthesis of semi-synthetic glycosaminoglycans of general formula III (see fig. I) with heparin or heparan structure modified in position 2 of the .alpha.-L-iduronic-2-O-sulfate acid in which the sulfate group is, entirely or i n part, substituted with a nucleophilic radical is described. Said process is carried out by treatin g glycosaminoglycans with heparin or heparan structure by means of a nucleophilic agent in alkaline medium.