发明名称 |
HEPATITIS C INHIBITOR PEPTIDE ANALOGUES |
摘要 |
Compound of formula (I) active against the Hepatitis C virus, wherein B is an acyl derivative; a is 0 or 1; R6, when present, is carboxy(lower)alkyl; b is 0 or 1; R5, when present, is C1-6 alkyl, or carboxy(lower)alkyl; Y is H or C1-6 alkyl; R4 is C1-10 alkyl; R3 is C1-10 alkyl; W is -NH-CH(R2)-C(O)-, wherein R2 is C1-6 alkyl; C6 or C10 aryl; C7-16 aralkyl; or carboxy(lower)alkyl; or W is a proline derivative; Q is a group of the formula -Z(R1)-C(O)-R13, wherein Z is CH or N; R1 is C1-6 alkyl or C1-6 alkenyl both optionally substituted with thio or halo; and R13 is an activated carbonyl substituent, or Q is a phosphonate group of the formula -CH(R1)-P(O)R15R16 wherein R15 and R16 are independently C6-20 aryloxy; and R1 is as defined above. |
申请公布号 |
WO9907734(A3) |
申请公布日期 |
1999.05.20 |
申请号 |
WO1998CA00764 |
申请日期 |
1998.08.10 |
申请人 |
BOEHRINGER INGELHEIM (CANADA) LTD.;LLINAS-BRUNET, MONTSE;BAILEY, MURRAY, DOUGLAS;HALMOS, TEDDY;POUPART, MARC-ANDRE;TSANTRIZOS, YOULA |
发明人 |
LLINAS-BRUNET, MONTSE;BAILEY, MURRAY, DOUGLAS;HALMOS, TEDDY;POUPART, MARC-ANDRE;TSANTRIZOS, YOULA |
分类号 |
A61K45/00;A61K31/13;A61K31/7056;A61K38/00;A61K38/21;A61P31/14;C07K7/06;C07K14/18 |
主分类号 |
A61K45/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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