发明名称 |
Anti-idiotype monoclonal antibodies, their use in active immunotherapy of malignant tumors and compositions containing them |
摘要 |
Monoclonal anti-idiotype antibody which is specific for murine antibodies against gangliosides carrying N-glycolylated sialic acid particularly against those gangliosides which are expressed by tumoral cells. The monoclonal antibody is useful as immunomodulator for the treatment of cancer. Specifically, the monoclonal anti-idiotype antibody of the present invention is capable of inducing a response which is predominantly anti-idiotypic in xenogenic models. The monoclonal anti-idiotype antibody also exerts a protector effect against malignant tumors in animals |
申请公布号 |
AU1019999(A) |
申请公布日期 |
1999.05.10 |
申请号 |
AU19990010199 |
申请日期 |
1998.10.21 |
申请人 |
CENTRO DE INMUNOLOGIA MOLECULAR (CIM) |
发明人 |
ANA MARIA VASQUEZ LOPEZ;ROLANDO PEREZ RODRIGUEZ;ELADIO IGLESIAS SIERRA;ALEXIS PEREZ GONZALEZ;GUMERSINDA BOMBINO LOPEZ;IRENE BEAUSOLEIL DELGADO |
分类号 |
C07K16/42;A61K39/00;A61K39/395;A61P35/00;C12N5/10;C12N5/20;C12N15/02;C12P21/08;C12R1/91 |
主分类号 |
C07K16/42 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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