A COMPOSITE VACCINE WHICH CONTAINS ANTIGEN, ANTIBODY AND RECOMBINANT DNA AND ITS PREPARING METHOD

摘要

The present invention provides a therapeutic vaccine complex and the preparing method thereof. The vaccine comprises a pathogenic microorganism-derived antigen, the corresponding antibody and a recombinant plasmid which contains the antigen-encoding DNAs. Specific humoral and cellular responses will be significantly enhanced by using the complex to induce the immune responses of low-response or immune tolerant subjects. The vaccine complex is characterized by the rapid immune response, the low effective dosage, the diversified antigen representation form and the stability. It can not only be used for the injection immunity but also for the local immunity such as respiratory mucosa. Experiments on mice showed that the anti-HBs positive ratio, anti-HBs titers and the corresponding specific cellular response are higher than those of the control group.