Method of reducing side effects associated with administration of oxygen-carrying proteins

摘要

A method of reducing side-effects associated with administering oxygen-carrying proteins to mammals is disclosed. The method includes: a) reacting an oxygen-carrying protein with a substantially non-antigenic polymer to form a oxygen-carrying protein-substantially non-antigenic polymer conjugate; and b) administering the oxygen-carrying protein-substantially non-antigenic polymer conjugate to a mammal in need of the oxygen-carrying protein. Preferred oxygen-carrying proteins include recombinantly prepared hemoglobins and preferred non-antigenic polymers include polyethylene glycol.