摘要 |
Substituted Indanylidineacetylguanidines, process for their preparation, their use as medicaments or diagnostic and medicaments containing them: Indanylidineacetylguanidines I and their pharmaceutically acceptable salts wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and X have the meanings given in the claims, are effective inhibitors of the cellular sodium/proton antiport (Na+/H+exchanger), which, in numerous diseases (essential hypertension, atherosclerosis, diabetes and the like) is also increased in those cells which are readily accessible for measurements, such as, for example, in erythrocytes, platelets or leukocytes. They are also advantageous for the preparation of a medicament for the treatment or prophylaxis of disorders of lipid metabolism.
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申请人 |
HOECHST AKTIENGESELLSCHAFT |
发明人 |
RAMAKRISHNA, NIROGI VENKATA SATYA;JAIN, ARUN KUMAR;LAL, BANSI;VADLAMUDI, RAO VENKATA SATYA VEERABHADRA;GHATE, ANIL VASANTRAO;GUPTE, RAVINDRA DATTATRAYA;WEICHERT, ANDREAS;SCHWARK, JAN-ROBERT |