发明名称 Substituted indanylidineacetylguanidines, processes for their preparation, their use as medicaments or diagnostics and medicaments containing them
摘要 Substituted Indanylidineacetylguanidines, process for their preparation, their use as medicaments or diagnostic and medicaments containing them: Indanylidineacetylguanidines I and their pharmaceutically acceptable salts wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and X have the meanings given in the claims, are effective inhibitors of the cellular sodium/proton antiport (Na+/H+exchanger), which, in numerous diseases (essential hypertension, atherosclerosis, diabetes and the like) is also increased in those cells which are readily accessible for measurements, such as, for example, in erythrocytes, platelets or leukocytes. They are also advantageous for the preparation of a medicament for the treatment or prophylaxis of disorders of lipid metabolism.
申请公布号 US5900436(A) 申请公布日期 1999.05.04
申请号 US19970901099 申请日期 1997.07.28
申请人 HOECHST AKTIENGESELLSCHAFT 发明人 RAMAKRISHNA, NIROGI VENKATA SATYA;JAIN, ARUN KUMAR;LAL, BANSI;VADLAMUDI, RAO VENKATA SATYA VEERABHADRA;GHATE, ANIL VASANTRAO;GUPTE, RAVINDRA DATTATRAYA;WEICHERT, ANDREAS;SCHWARK, JAN-ROBERT
分类号 A61K31/155;A01N1/00;A61K31/165;A61P3/06;A61P9/00;A61P9/06;A61P9/10;A61P9/12;A61P25/00;A61P43/00;C07C279/22;C07C327/50;C07C327/54;(IPC1-7):A61K31/165;C07C231/02;C07C233/09 主分类号 A61K31/155
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