| 摘要 |
The present invention relates to non-psychoactive derivatives of tetrahydro-cannabinol, which exhibit anti-inflammatory, analgesic and leukocyte antiadhesion activities. The invention includes novel derivatives of (3R,4R)- DELTA <8>-tetrahydrocannabinol-11-oic acids (hereinafter referred to as (3R,4R)- DELTA <8>-THC-11-oic acid), as well as pharmaceutical compositions containing the (3R,4R)- DELTA <8>-THC-11-oic acid derivatives. The invention further covers methods of administering the novel derivatives and pharmaceutical compositions as therapeutic agents in the treatment of pain and tissue inflammation. Non-psychoactive derivatives of DELTA <8>-THC-11-oic acid are described which have analgesic and anti-inflammatory properties.
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