| 摘要 |
Composition, and methods of use thereof, for the inhibition of tumor growth and killing of tumors having extensive microcirculation wherein the active agent is a compound blocking the protein C s ystem, preferably anti-protein C antibody, anti-protein S antibody and C4b binding protein. In the most preferred embodiment, the protei n C blocking compound is provided in combination with a cytokine such as tumor necrosis factor (TNF), gamma interfero n, interleukin-1, interleukin-2 and granulo-cytemacrophage colony stimulating factor. Example are provided demonstra ting the administration of the protein C blocking compound, alone or in combination with TNF, to dogs having canine venereal tumor s, a fibrosarcoma, and an adenocarcinoma, to pigs with melanoma, and a primate with a malignant lymphoma, followed by sign ificant tumor reduction.
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