DERIVATIVES OF THIAZOLIDINEDIONE, THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION

摘要

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to compounds of the formula (I) where n is a whole number from 1 to 3; A is a fragment of 5-membered aromatic heterocycle containing at least one nitrogen atom which is bound through carbon atom which is an adjacent with heterocyclic nitrogen atom and can be substituted with lower alkyl, C3-C6-cycloalkyl, phenyl, naphthyl or aromatic 5-membered heterocycle containing oxygen or sulfur atom; is a simple bond or a double bond, or their pharmacologically acceptable salts and methods of their synthesis and a pharmaceutical composition on their basis showing hypoglycemic and hypolipidemic activity. Invention can be used in medicine as a drug for treatment of diabetic patients. EFFECT: improved method of synthesis, compounds are used as drugs. 11 cl, 10 tbl, 74 ex