| 摘要 |
FIELD: organic chemistry, biochemistry, pharmacy. SUBSTANCE: invention relates to new compounds of the formula (I) <EMI ID=0.87 HE=27 WI=72 TI=CHI> where R<SB>1</SB> and R<SB>2</SB> each independently means chlorine, bromine, iodine atoms or a group OSO<SB>2</SB>Me; R and R - hydrogen atom; R<SB>3</SB> and R<SB>4</SB> - hydrogen atom; R and R - hydrogen atom, C<SB>1-4</SB>-alkyl, haloid; R and R form -CH=CH-CH=CH-; R and R - hydrogen atom, cyano-group, haloid; X means O, NH, -CH<SB>2</SB>-; Y means O; Z means -V-W where V means -CH<SB>2</SB>T- where T means -CH<SB>2</SB>- or -S-; W means COOH, -(C=O)NR<SB>7</SB>R<SB>8</SB> where R<SB>7</SB> - hydrogen atom, C<SB>1-6</SB>-alkyl and the others; R<SB>8</SB> - hydrogen atom and their salts. Method of synthesis of compounds of the formula (I) involves removal of protection in compound of the formula (Ia) <EMI ID=0.88 HE=27 WI=72 TI=CHI>. Invention proposes a pharmaceutical composition containing an effective amount of compound of the formula (I) and a bicomponent system for delivery of cytotoxic drug consisting of antibody or its fragment which are able to bind a definite antigen. Antigen or its fragment are conjugated with an enzyme CPG which is able to convert a compound of the formula (I) or its salt to a cytotoxic drug and has additionally a compound of the formula (I) or its salt which are converted to a cytotoxic drug by an enzyme CPG effect. EFFECT: improved method of synthesis and drug delivery. 16 cl, 12 dwg, 18 tbl, 46 ex
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