| 摘要 |
<p>The invention relates to a family of mammalian genes that are transcribed in the immediate early phase following exposure to Fibroblast Growth Factors (FGF) during mesoderm induction, termed Mesoderm Induction Immediate Early Response (MIER) genes. Defining features of the members of this family include that these genes are a) transcribed in reponse to fibroblast growth factors (FGF); b) are expressed within 40 minutes of FGF treatment; and c) do not require protein synthesis for transcription. There are at least 11 element members within this family. The invention relates generally to compositions of and diagnostic methods relating to the M-MIER gene family, cDNA, nucleotide fragments, polypeptides coded thereby, recombinant host cells and vectors containing M-MIER encoding polynucleotide sequences, recombinant M-MIER polypeptides, antibodies, assays designed to select substances which interact with M-MIER polypeptides, diagnostic and therapeutic applications, drug design and DNA vaccination methodologies.</p> |
