| 摘要 |
<p>The present invention encompasses structures of Formula (I) or the pharmaceutically acceptable non-toxic salts thereof, wherein: X is oxygen, H2, or sulfur; Y is oxygen or sulfur; W is alkyl, arylalkyl, or heteroarylalkyl, each of which is optionally substituted; or W is aryl or heteroaryl; (a) represents (b), (c), (d), wherein: Z1, Z2, Z3 and Z4 independently represent nitrogen or C-Ra, where each Ra independently is hydrogen, an inorganic substituent or an optionally substituted aromatic group; n is 1, 2 or 3; and Rb is hydrogen, alkyl, or an optionally substituted aromatic group, which compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs thereof and are useful in the diagnosis and treatment of anxiety, sleep, and seizure disorders, overdose with benzodiazepine drugs, and enhancement of memory.</p> |
