发明名称 |
TRANSCRIPTIONAL INTERMEDIARY FACTOR-2 (TFIF2) |
摘要 |
The present invention concerns a nuclear receptor (NR) transcriptional mediator. More specifically, isolated nucleic acid molecules are provided encoding transcriptional intermediary factor-2 (TIF2). Recombinant methods for making TIF2 polypeptides are also provided as are TIF2 antibodies. Screening methods are also provided for identifying agonists and antagonists of the activation function AF-2 of nuclear receptors, for identifying agonists and antagonists of the AD1 activation domain activity of TIF2, and for identifying agonists and antagonists of the AD2 activation domain activity of TIF2. |
申请公布号 |
WO9802455(A3) |
申请公布日期 |
1999.04.08 |
申请号 |
WO1997US12100 |
申请日期 |
1997.07.11 |
申请人 |
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE;UNIVERSITE LOUIS PASTEUR;BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
CHAMBON, PIERRE;GRONEMEYER, HINRICH;VOEGEL, JOHANNES;LUTZ, YVES |
分类号 |
C07K14/47;C12N15/12 |
主分类号 |
C07K14/47 |
代理机构 |
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代理人 |
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