METHOD TO PRODUCE POLYKETIDES AND POLYKETIDES

摘要

Modified PKS gene clusters which produce novel polyketides in an efficient system in a host cell or in a cell free extract are described. The novel polyketides result from the incorporation of diketides of formula (1) or (2), wherein A is a moiety that activates the diketide, and at least one of R<1> and R<2> is a substituent other than that natively occuring in the diketide normally processed by the modified PKS cluster. The polyketides may also be glycosylated to provide antibiotics.