发明名称 |
GENE THERAPY APPROACHES TO SUPPLY APOLIPOPROTEIN A-I AGONISTS AND THEIR USE TO TREAT DYSLIPIDEMIC DISORDERS |
摘要 |
The invention relates to genetic approaches to supply nucleotide sequences encoding modified forms of the native forms of apolipoprotein A-I (ApoA-I): mature ApoA-I, preproApoA-I and proApoA-I; including native ApoA-I modified to contain ApoA-I agonists, peptides which mimic the activity of ApoA-I; ApoA-I superagonists, peptides which exceed the activity of native ApoA-I; and modified native ApoA-I having one or more amphipathic helices replaced by the nucleotide sequences of one or more ApoA-I agonists; for the treatment of disorders associated with dyslipoproteinemia, including cardiovascular disease, atherosclerosis, restenosis, hyperlipidemia, and other disorders such as septic shock.
|
申请公布号 |
WO9916409(A2) |
申请公布日期 |
1999.04.08 |
申请号 |
WO1998US20329 |
申请日期 |
1998.09.28 |
申请人 |
DASSEUX, JEAN-LOUIS;SEKUL, RENATE;BUTTNER, KLAUS;CORNUT, ISABELLE;METZ, GUNTHER;DUFOURCQ, JEAN |
发明人 |
DASSEUX, JEAN-LOUIS;SEKUL, RENATE;BUTTNER, KLAUS;CORNUT, ISABELLE;METZ, GUNTHER;DUFOURCQ, JEAN |
分类号 |
C12N15/09;A61K38/00;A61K38/16;A61K48/00;A61P3/00;A61P3/06;A61P9/00;A61P9/10;A61P31/04;A61P43/00;C07H21/00;C07K7/06;C07K7/08;C07K14/00;C07K14/47;C07K14/775;C12N5/10;(IPC1-7):A61K/ |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|