| 摘要 |
PCT No. PCT/FI96/00004 Sec. 371 Date May 13, 1997 Sec. 102(e) Date May 13, 1997 PCT Filed Jan. 3, 1996 PCT Pub. No. WO96/22531 PCT Pub. Date Jul. 25, 1996The object of this invention is an improved method for biospecific multiparameter assay method based on the use of different categories of microparticles as solid support for different bioaffinity reagents. This invention allows the use of microparticles of small size and with very moderate monodispersity and conventional short decay time fluorescent labels for labelling the biospecific reactants. The high sensitivity of this method is based on the use of confocal excitation and detection, or alternatively, two-photon excitation for measurement of the biospecific reaction. The identification of the category of the microparticle is based on the use of fluorescent or Raman scattering indicators associated with the microparticles representing different analytes.
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