Peptide derived from human immunodeficiency virus type 1 (HIV-1), isolate ant70, containing an immunodominant epitope and it's use in immunodiagnostic assays

摘要

PCT No. PCT/EP93/00517 Sec. 371 Date Nov. 22, 1993 Sec. 102(e) Date Nov. 22, 1993 PCT Filed Mar. 8, 1993 PCT Pub. No. WO93/18054 PCT Pub. Date Sep. 16, 1993This invention is directed toward a peptide corresponding to an immunologically important viral epitope. Specifically, the peptide corresponds to an immunodominant epitope identified in the gp41 region of the human immunodeficiency virus type 1 (HIV-1), strain Ant70. This peptide has the following amino acid sequence: NH2-Leu-Trp-Gly-Cys-Lys-Gly-Lys-Leu-Val-Cys-CO2H. The invention also relates to the use of this peptide, particularly when biotinylated in the form of complexes of streptavidin-biotinylated peptides or of avidin-biotinylated peptides, for the in vitro determination of HIV-1-specific antibodies.