| 摘要 |
<p>PROBLEM TO BE SOLVED: To safely and easily produce the subject compound that is useful as a synthetic intermediate for antidiabetic agent by allowing an acetophenone derivative to react with a compound prepared in the reaction system in the presence of a palladium complex catalyst. SOLUTION: (A) A compound of formula I (X is halogen, preferably Br or I) is allowed to react with (B) a compound of formula II (Y is a halogen, suitably Cl) prepared in the reaction system in the presence of (C) a palladium complex catalyst [suitably tetrakis(triphenylphosphine) palladium, palladium acetate/phosphine] to prepare (D) 4'-(2-pyridyl)acetophenone. In a preferred embodiment, the amount of the component B is 1.0-10.0 equivalents, the amount of the component C is 0.1-50 mol.% based on the component A. This preparative reaction is preferably carried out in a solvent and pyrrolidones, aromatic hydrocarbons and others are used as a solvent.</p> |
