A chimeric G alpha protein having yeast G alpha (Gpa1p) amino acid sequences modified by a minimum of 3 amino acids positions within the C-terminal 10 amino acids by substitution by alternative amino acids, a transformed yeast cell comprising said chimeric G alpha protein and a method of screening for a compound able to interact with a receptor comprising contacting a compound of interest with said yeast cell and observing the growth response of the cell or observing production of a reporter gene product.
申请公布号
WO9914344(A1)
申请公布日期
1999.03.25
申请号
WO1998GB02759
申请日期
1998.09.11
申请人
GLAXO GROUP LIMITED;BROWN, ANDREW, JAMES;DOWELL, SIMON, JEREMY