发明名称 |
CATIONIC VIROSOMES AS TRANSFER SYSTEM FOR GENETIC MATERIAL |
摘要 |
<p>The present invention relates to a positively charged virosome for efficient delivery of genetic material to resting or proliferating mammalian cells in vitro and in vivo. The virosome membrane contains cationic and/or polycationic lipids, at least one viral fusion peptide and preferably at least one cell-specific marker, advantageously selected from the group consisting of monoclonal antibodies, antibody fragments F(ab')2 and Fab', cytokines, and growth factors, for a selective detection and binding of target cells. The invention further relates to a method for the manufacture of the novel virosomes and to applications thereof, particularly for the manufacture of pharmaceutical compositions to treat cancer or leukemia.</p> |
申请公布号 |
EP0902682(A2) |
申请公布日期 |
1999.03.24 |
申请号 |
EP19970921852 |
申请日期 |
1997.05.04 |
申请人 |
NIKA HEALTH PRODUCTS LIMITED |
发明人 |
WAELTI, ERNST, RUDOLF;GLUECK, REINHARD;KLEIN, PETER |
分类号 |
A61K9/127;A61K31/00;A61K47/16;A61K48/00;A61P35/00;A61P35/02;C12N15/88;(IPC1-7):A61K9/127 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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