发明名称 |
Homocyclic and heterocyclic compounds suitable for use in oligonucleotide synthesis |
摘要 |
A support carrying a homocyclic or heterocyclic ring containing a first and second carbon atom wherein: (i) the first carbon atom is substituted by a nucleophilic group or a group convertible to a nucleophilic group on treatment with base; (ii) the second carbon atom is substituted by a hydroxy group, a hydroxy group protected by an acid labile protecting group, or a phosphate group substituted by an oligonucleotide; and (iii) the first and second carbon atoms are directly connected by a covalent bond; which is suitable for use in oligonucleotide synthesis. Methods for its preparation and use, and novel compounds for attachment to the support are described.
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申请公布号 |
US5886193(A) |
申请公布日期 |
1999.03.23 |
申请号 |
US19970853673 |
申请日期 |
1997.05.09 |
申请人 |
ZENECA LIMITED |
发明人 |
MCLEAN, MICHAEL JOSEPH;GARMAN, ANDREW JOHN |
分类号 |
C07H21/04;C07C59/11;C07D307/20;C07F9/6558;C07F9/6561;C07H21/00;(IPC1-7):C07C69/67;C07D207/08;C07D307/12;C07D333/10 |
主分类号 |
C07H21/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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