A PROCESS FOR THE SYNTHESIS OF MODIFIED P-CHIRAL NUCLEOTIDE ANALOGUES
摘要
The process of the instant invention is drawn to the synthesis of modified P-chiral nucleotide analogues in the form of pure diastereomers possessing preselected configuration at the P-atom. Oligonucleotides prepared by the method of the invention containing P-chiral compounds have enhanced hybridization and transporting properties.
申请公布号
WO9849179(A3)
申请公布日期
1999.03.18
申请号
WO1998PL00014
申请日期
1998.04.23
申请人
POLSKA AKADEMIA NAUK, CENTRUM BADAN MOLEKULARNYCH I MAKROMOLEKULARNYCH;STEC, WOJCIECH, J.;WOZNIAK, LUCYNA, A.;CHWOROS, ARKADIUSZ;PYZOWSKI, JAROSDAW