发明名称 |
Compositions and methods for preventing and treating allograft rejection |
摘要 |
Compositions and methods are provided for the prevention and treatment of allograft rejection. Compositions are provided which comprise an antisense oligonucleotide targeted to a nucleic acid sequence encoding intercellular adhesion molecule-1, vascular cell adhesion molecule-1, or endothelial leukocyte adhesion molecule-1 in combination with an immunosuppressive agent. Methods of preventing or treating allograft rejection by treating an allograft recipient with such a composition are provided. Methods for preventing allograft rejection comprising perfusion of the graft are also provided.
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申请公布号 |
US5883082(A) |
申请公布日期 |
1999.03.16 |
申请号 |
US19940344155 |
申请日期 |
1994.11.23 |
申请人 |
ISIS PHARMACEUTICALS, INC.;BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
BENNETT, C. FRANK;STEPKOWSKI, STANISLAW M. |
分类号 |
A61K38/00;A61K39/395;A61K48/00;C07K14/705;C12N15/113;(IPC1-7):C07H21/04 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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