IMMUNOSTIMULATING AND IMMUNOPOTENTIATING RECONSTITUTED INFLUENZA VIROSOMES AND VACCINES CONTAINING THEM

摘要

Disclosed are immunostimulating reconstituted influenza virosomes (IRIVs) compri sing the following components: (a) a mixture of phospholipids; (b) essentially reconstituted functional virus envelop es; (c) an influenza hemagglutinin protein (HA) or a derivative thereof which is biologically active and capable of inducing the fusion of said IRIV with cellular membranes and of inducing the lysis of said IRIV after endocytosis by antigen presenting cells , preferably macrophages or B cells; and (d) an antigen, and vaccines containing these IRIVs.