| 摘要 |
PROBLEM TO BE SOLVED: To obtain the subject novel compound that is useful as a therapeutic and preventive agent for cerebral function restriction caused by transplantation, head injury, cardiac arrest, acute and/or chronic neurological disorders as an antagonist of metabotropic glutamate receptor and/or as an agonist. SOLUTION: This compound is represented by formula I (R<1> is H, a lower alkoxy or the like; R<2> is a lower alkyl, a lower alkoxy or the like; R<3> -R<12> are each H, a halogen or the like) or its salt, typically (RS)-2-(2,6- dichlorophenyl)-5-(2-methoxyphenyl)-7-methyl-5H-thiazolo [3,2- a]pyrimidine-6-carboxylic 2-dimethylaminoethyl ester. This compound is prepared by reaction of a compound of formula II withα-bromo-acetaldehyde, when necessary, in addition, converting the compound of formula I to its salt. The intermediate compound of formula II is novel and is prepared, for example, by reaction of 4-metoxybenzaldehyde with acetylacetone and thiourea.
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