| 摘要 |
This invention relates to novel compounds of Formula (I), and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8). Compounds of Formula (I) are represented, interalia, by structure (I) wherein interalia, R is -NH-C(X)-NH- (CR13R14)v-Z; Z is optionally substituted phenyl or napthyl, optionally substituted heteroaryl, optionally substituted C5-8 cycloalkyl, optionally substituted C1-10 alkyl, optionally substituted C2-10 alkenyl, or an optionally substituted C2-10 alkynyl; X is =O, or =S; A is a mono- or di-substituted carbon as defined herein; v is 0, or an integer having a value of 1 to 4; or a pharmaceutically acceptable salt thereof.
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