Method for producing drug-loaded microparticles and an ICAM-1 dosage form so produced

摘要

Method of producing microparticles loaded with biologically active drugs, including proteins such as ICAM-1, for controlled release of the drugs in a nasal passageway. The method includes introducing a drug/polymer feed solution and an emulsifier into a first mixing chamber to create an emulsion, then mixing a cross-linking agent together with the emulsion under controlled conditions to create microparticles loaded with the drug in a second mixing chamber. The formed microparticles are filtered and deaggregated to form individual microparticles that then may be formulated for nasal passageway delivery.