发明名称 |
Anvendelse av T-BAM (CD40L) ved behandling av sykdommer i glatt muskulatur |
摘要 |
<p>Activation of smooth muscle cells bearing CD40 on their cell surface by CD40 ligand is inhibited by contacting the smooth muscle cells with an anti-T-BAM (CD40L) antibody capable of inhibiting the interactions between CD40 ligand and the CD40-bearing smooth muscle cells, in an amount effective to inhibit activation of the smooth muscle cells. Activation of smooth muscle cells bearing CD40 on their surface by CD40 ligand in a subject is inhibited by administering to the subject an anti-T-BAM (CD40L) antibody capable of inhibiting the interaction between CD40 ligand and the smooth muscle cells, in an amount effective to inhibit activation of the cells. Conditions dependent on CD40 ligand-induced activation of CD40-bearing cells smooth muscle cells are treated, in particular inflammatory bowel disease.</p> |
申请公布号 |
NO990019(A) |
申请公布日期 |
1999.03.08 |
申请号 |
NO19990000019 |
申请日期 |
1999.01.04 |
申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK;BIOGEN INC |
发明人 |
YELLIN, MICHAEL J.;LEDERMAN, SETH;CHESS, LEONARD;KARPUSAS, MIHAIL N.;THOMAS, DAVID W. |
分类号 |
C12N15/02;A61K38/00;A61K38/17;A61K39/395;A61K45/00;A61P1/00;A61P9/00;A61P9/10;A61P13/10;A61P17/00;C07K14/705;C07K16/28;C12P21/08;C12R1/91;(IPC1-7):A61K38/00;A61K38/16;A61K38/02 |
主分类号 |
C12N15/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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