发明名称 |
COMPOSITIONS COMPRISING THE ADJUVANT QS-21 AND POLYSORBATE OR CYCLODEXTRIN AS EXCIPIENT |
摘要 |
Certain novel compositions of the adjuvant saponin QS-21 having improved properties are disclosed. The compositions of the present invention are designed (1) to minimize the lytic effects of QS-21, (2) to improve the tolerance of QS-21 containing formulations in humans or other animals, (3) to stabilize the QS-21 from alkaline hydrolysis and/or (4) to maintain the high adjuvant potency of the QS-21 product. These compositions may be employed with vaccines comprising proteins or peptides, polysaccharides, lipids, or nucleic acids. |
申请公布号 |
WO9910008(A1) |
申请公布日期 |
1999.03.04 |
申请号 |
WO1998US17940 |
申请日期 |
1998.08.28 |
申请人 |
AQUILA BIOPHARMACEUTICALS, INC. |
发明人 |
KENSIL, CHARLOTTE;BELTZ, GERALD, A. |
分类号 |
A61K9/00;A61K39/39;A61K47/10;A61K47/26;A61K47/40;A61K47/42;A61P37/04 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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