POMPILID WASP-DERIVED NEUROPEPTIDES

摘要

The present invention provides a peptide represented by the amino acid sequence formula (A): H-X1-X2-X3-X4-Gly-X6-X7-Asp-Gln-R wherein: each of X1 and X3 independently represents Arg or Lys, each of X2, X4 and X6 independently represents Ile or Leu, and X7 represents Phe, Tyr or Trp; and R represents -NH2, -Leu-NH2, -Leu-Ser-NH2, -Leu-Ser-Lys-NH2, -Leu-Ser-Arg-NH2, Leu-Ser-Lys-Leu-NH2, or -Leu-Ser-Arg-Leu-NH2; and a salt thereof. In the above, Gly stands for a glycine residue, Asp stands for an aspartic acid residue, Gln stands for a glutamine residue, Arg stands for an arginine residue, Lys stands for a lysine residue, Ile stands for an isoleucine residue, Leu stands for a leucine residue, Phe stands for a phenylalamine residue, Tyr stands for a tyrosine residue, Trp stands for a tryptophan residue, and Ser stands for a serine residue. The peptide acts on glutamate receptors and is expected to be useful in the treatment of cerebral nerve diseases associated with glutamic acid.