发明名称 |
Device for detecting free IGFBP-1 |
摘要 |
Antibodies having binding affinity for free IGFBP-1, biological compositions including antibodies having binding affinity for free IGFBP-1, kits for detecting free IGFBP-1 using the antibodies, and cell lines for producing the antibodies are provided. Also provided are devices and methods for detecting free IGFBP-1 and a rupture in a fetal membrane based on the presence of amniotic fluid in a vaginal secretion, as indicated by the presence of free IGFBP-1 in the vaginal secretion. The antibodies that are provided may be characterized by their ability to selectively recognize those IGFBP-1 molecules which are free of IGF-1 and IGF-2, i.e., antibodies which have a binding affinity for free IGFBP-1 that is greater than a binding affinity of the antibody to bound IGFBP-1. These antibodies may also be characterized by their competition with IGF-1 and IGF-2 for binding to IGFBP-1.
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申请公布号 |
US5877029(A) |
申请公布日期 |
1999.03.02 |
申请号 |
US19960738248 |
申请日期 |
1996.10.28 |
申请人 |
CALIFORNIA RESEARCH LLC |
发明人 |
FUKS, BORIS;BOLTOVSKAYA, MARINA;KONSTANTINOV, ALEXANDER;NAZIMOVA, SVETLANA;STAROSVETSKAYA, NELLI;STEPANOV, ALEXANDER;ZARAISKY, EVGENY |
分类号 |
G01N33/53;G01N33/543;G01N33/558;G01N33/68;G01N33/74;(IPC1-7):G01N33/558 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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