Human glial cell line-derived neurotrophic factor promoters, vectors containing same, and methods of screening compounds therewith

摘要

The distal and proximal promoters for the human glial cell line-derived neurotrophic factor (GDNF) gene are provided. In addition, constructs comprising a human GDNF promoter and a reporter gene, a vector comprising the construct and a host cell comprising the vector are provided, as is a method for screening compounds capable of modulating the expression of GDNF by stimulating GDNF promoter-directed transcription.