摘要 |
Therapeutic compounds and methods for modulating amyloid deposition in a subject, whatever its clinical setting, are described. Amyloid deposition is modulated by the administration to a subject of an effective amount of a therapeutic compound comprising a phosphonate group and a carboxylate group, a congener thereof, or a pharmaceutically acceptable salt or ester thereof. In preferred embodiments, an interaction between an amyloidogenic protein and a basement membrane constituent is modulated.
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申请人 |
QUEEN'S UNIVERSITY AT KINGSTON;SZAREK, WALTER, A.;KONG, XIANGI;THATCHER, GREGORY, R., J.;GORINE, BORIS |
发明人 |
SZAREK, WALTER, A.;KONG, XIANGI;THATCHER, GREGORY, R., J.;GORINE, BORIS |