发明名称 |
Use of cell membrane permeants in the treatment of cellular proliferative diseases |
摘要 |
Methods are provided for the treatment of a host suffering from a cellular proliferative disease through administration of a chemotherapeutic agent in conjunction with a cell membrane permeant. Optionally, the cell membrane permeant and/or chemotherapeutic agent will be present in a pharmaceutically acceptable vehicle capable of acting as a depot. In the subject methods, the chemotherapeutic agent and membrane permeant are administered at least proximal to a target site of the host. Administration of chemotherapeutic agents in accordance with the subject methods results in improved efficacy of, and/or decreased host toxicity to, the intralesionally administered chemotherapeutic agent.
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申请公布号 |
US5874402(A) |
申请公布日期 |
1999.02.23 |
申请号 |
US19970857736 |
申请日期 |
1997.05.16 |
申请人 |
MATRIX PHARMACEUTICAL, INC. |
发明人 |
SINGH, SAIRA;JONES, RICHARD E.;BROWN, DENNIS M. |
分类号 |
A61K47/00;A61K31/00;A61K31/475;A61K38/00;A61K38/19;A61K47/26;A61K47/28;A61K47/42;A61K47/46;A61P35/00;(IPC1-7):A61K38/00;A61K31/435 |
主分类号 |
A61K47/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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