摘要 |
<p>A bisheterocyclic compound represented by general formula (I), stereoisomers thereof, tautomers thereof, a pharmaceutically acceptable salt or a pharmaceutically acceptable solvate thereof, a pharmaceutical composition containing the same, and a process for the production thereof. In formula (I), R<1> and R<2> may be the same or different from each other and each represents (II) or (III), R3 represents hydrogen or a protective group, X, Y<1> and Y<2> may be the same or different from one another and each represents oxygen or sulfur, B<1> and B<2> represent each phenylene, B<3> represents phenylene, naphthylene, cyclohexylene or furo[3,2-b]furanylene, L<1> and L<2> represent each -(O)n-A-, n represents 0 or 1, and A represents a single bond or lower alkylene, provided that when n is 1, A represents alkylene and the oxygen atom of each of L<1> and L<2> is bonded to B<3>. The above compounds are useful as a hypoglycemic drug based on the activity of enhancing insulin sensitivity. <CHEM></p> |
申请人 |
YAMANOUCHI PHARMACEUTICAL CO., LTD., TOKIO/TOKYO, JP |
发明人 |
NIIGATA, KUNIHIRO 287, NAKABUN 2-CHOME, SAITAMA 362, JP;TAKAHASHI, TAKUMI 5-9, NINOMIYA 2-CHOME, IBARAKI 305, JP;YONEDA, TAKASHI 6-1, AKEBONO 4-CHOME, CHIBA 277, JP;NOSHIRO, OSAMU 2240-79, WAKASHIBACHO, IBARAKI 301, JP;KOIKE, REIKO 1456, OHAZA SHIMOINAYOSHI, NIIHARI-GUN IBARAKI 315, JP;SHIMAYA, AKIYOSHI 5-9, NONOMIYA 2-CHOME, IBARAKI 305, JP |