1-A-ALPHA-HYDROXYLASE MATERIALS AND METHODS

摘要

The invention is directed to polynucleotides encoding all or a fragment of the P450 moiety of vitamin D 1-.alpha.-Hydroxylase and polypeptides encoded thereby. It encompasses antibodies to the polynucleotides and hybridizing polynucleotides. The polynucleotides and polypeptides are used in methods of diagnosing and treating vitamin D-related disorders and of producing vitamin D metabolites. The invention also encompasses expression vectors and animal cells comprising the polynucleotides.