发明名称 |
CYCLIC PEPTIDE ANTIFUNGAL AGENTS |
摘要 |
The present invention provides phosphonylating agents and phosphonylation conditions that are compatible with the acid- and base-sensitive compounds and which promote a regioselective and reproducible conversion to a phosphonate compound. Also provided are intermediates that may be used to prepare phosphonate derivatives of cyclic peptides antifungal agent and a process for converting the phosphonates to the desired phosphonic acid prodrugs.
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申请公布号 |
CA2301184(A1) |
申请公布日期 |
1999.02.11 |
申请号 |
CA19982301184 |
申请日期 |
1998.08.03 |
申请人 |
ELI LILLY AND COMPANY |
发明人 |
HANSEN, MARVIN MARTIN;GRUTSCH, JOHN LEO JUNIOR;UDODONG, UKO EFFIONG;HARKNESS, ALLEN ROBERT;VERRAL, DANIEL EDWARD II |
分类号 |
A61K38/00;C07F9/40;C07H13/00;C07K7/56;(IPC1-7):C07K7/56;C07K1/113;A61K38/12 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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地址 |
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