发明名称 |
Method for the production of dicarboxylic acids |
摘要 |
The present invention is an economical fermentation method for the production of carboxylic acids comprising the steps of a) inoculating a medium having a carbon source with a carboxylic acid-producing organism; b) incubating the carboxylic acid-producing organism in an aerobic atmosphere to promote rapid growth of the organism thereby increasing the biomass of the organism; c) controllably releasing oxygen to maintain the aerobic atmosphere; d) controllably feeding the organism having increased biomass with a solution containing the carbon source to maintain the concentration of the carbon source within the medium of about 0.5 g/L up to about 1 g/L; e) depriving the aerobic atmosphere of oxygen to produce an anaerobic atmosphere to cause the organism to undergo anaerobic metabolism; f) controllably feeding the organism having increased biomass a solution containing the carbon source to maintain the concentration of the carbon source within the medium of >/=1 g/L; and g) converting the carbon source to carboxylic acids using the anaerobic metabolism of the organism.
|
申请公布号 |
US5869301(A) |
申请公布日期 |
1999.02.09 |
申请号 |
US19970792655 |
申请日期 |
1997.01.31 |
申请人 |
LOCKHEAD MARTIN ENERGY RESEARCH CORPORATION |
发明人 |
NGHIEM, NHUAN PHU;DONNELLY, MARK;MILLARD, CYNTHIA S.;STOLS, LUCY |
分类号 |
C12N15/09;C12N1/21;C12N1/38;C12N9/04;C12P7/06;C12P7/40;C12P7/44;C12P7/46;C12P7/54;C12R1/19;C12R1/225;(IPC1-7):C12P7/40 |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|