| 摘要 |
<p>PROBLEM TO BE SOLVED: To obtain the subject new compound having activities for selectively suppressing the production of IgE and IL-5, capable of manifesting activities in the immediate and chronic allergy, and becoming an active ingredient of antiallergic agent. SOLUTION: The subject compound is a phthalimide derivative of the formula [R<1> to R<4> are each H, hydroxy group, a lower alkyl, carbamoyl, amino, nitro, etc.; A is N atom, etc.; B is H, a lower alkyl, a cycloalkyl, an aryl, etc.; X is 1-4C alkylene, etc.; Y is O atom, S atom, etc.; Z is a 1-4C alkylene, a 2-4C alkenylene, etc.; (l), (m) and (n) are each independently 0 or 1; Cy is an aryl, a heterocyclic group, etc.] or a pharmaceutically acceptable salt thereof. For example, 2-[(S) -2-benzyloxy -1-phenylethyl] -2,3-dihydro -1,3-dioxo -1H -isoindole -5-carboxylic acid is cited. An antiallergic agent having both effectiveness and safety is provide by using the compound of the formula as an active ingredient.</p> |
