发明名称 |
Resolution of amines |
摘要 |
The procedure comprises reacting the mixture that comprises 2-Äphenyl(1-methyl-1H-pyrazole-5-yl)methoxyÜ-N,N-dimethylethanamine (I) with an enantiomer of an optically active acid to form a diastereoisomeric salt, separating said salt and liberating the enantiomer of said compound (I). The dextrorotatory enantiomer of (I) can be obtained by reacting a racemic mixture or non-racemic mixture of (I) with (+)-ditoluyl-L-tartaric acid, optionally mixed with p-toluensulphonic acid. Compound (I) has analgesic properties and its most active enantiomer is dextrorotatory. |
申请公布号 |
AU8111798(A) |
申请公布日期 |
1999.02.08 |
申请号 |
AU19980081117 |
申请日期 |
1998.07.06 |
申请人 |
LABORATORIOS DEL DR. ESTEVE, S.A. |
发明人 |
ANTONI TORRENS JOVER;JORDI FRIGOLA CONSTANSA |
分类号 |
A61K31/415;A61P29/00;C07D231/12 |
主分类号 |
A61K31/415 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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