发明名称 |
ANTI-INVASIVE AND ANTI-ANGIOGENIC UROKINASE FRAGMENTS AND THEIR USE |
摘要 |
A peptide compound having the sequence Lys-Pro-Ser-Ser-Pro-Pro-Glu-Glu ¢SEQ ID NO:2! or a substitution variant, addition variant or other chemical derivative thereof inhibits cell invasion, endothelial tube formation or angiogenesis in vitro. A number of substitution variants and addition variants of this peptide, preferably capped at the N- and C-termini, as well as peptidomimetic derivatives, are useful for treating diseases and conditions mediated by undesired and uncontrolled cell invasion and/or angiogenesis. Pharmaceutical compositions comprising the above peptides and derivatives are administered to subjects in need of such treatment in a dosage sufficient to inhibit invasion and/or angiogenesis. The disclosed compositions and methods are particularly useful for suppressing the growth and metastasis of tumors.
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申请公布号 |
CA2269772(A1) |
申请公布日期 |
1999.02.04 |
申请号 |
CA19982269772 |
申请日期 |
1998.07.24 |
申请人 |
ANGSTROM PHARMACEUTICALS, INC. |
发明人 |
JONES, TERENCE R.;MAZAR, ANDREW P. |
分类号 |
A61K38/00;A61P35/00;C12N9/72;(IPC1-7):C12N9/72;A61K38/49 |
主分类号 |
A61K38/00 |
代理机构 |
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