The invention provides crystalline forms of adefovir dipivoxil and methods to prepare the crystals. The compositions and methods of the present invention have desirable properties for large scale synthesis of crystalline adefovir dipivoxil or for its formulation into therapeutic dosages. Invention compositions include an anhydrous crystal form of adefovir dipivoxil.
申请公布号
CA2298057(A1)
申请公布日期
1999.02.04
申请号
CA19982298057
申请日期
1998.07.23
申请人
GILEAD SCIENCES, INC.
发明人
MANES, LAWRENCE V.;ARIMILLI, MURTY N.;LEE, THOMAS T. K.;MUNGER, JOHN D., JR.;KELLY, DAPHNE E.;SCHULTZE, LISA M.;PRISBE, ERNEST J.