PRODUCTION OF HUMAN MUTANT PROTEINS IN HUMAN CELLS BY HOMOLOGOUS RECOMBINATION

摘要

A process is disclosed for producing mutant proteins of eukaryotic polypeptides in eukaryotic cells by homologous recombination. Also disclosed is a process for producing human cells suitable for producing human mutant proteins. Finally, the invention concerns the human cells produced by this process and the mutant human proteins obtained therefrom, as well as pharmaceutical compositions containing these mutant proteins.